Endocrine Abstracts

Recent studies in various species have pointed out that Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, are important regulators of reproduction. NKB is co-expressed in Kiss1 neurons of the arcuate nucleus (ARC) and stimulates, via auto-regulatory loops, kisspeptin output onto GnRH neurons, therefore stimulating gonadotropin secretion. However, important aspects of the roles of NKB as regulators of the gonadotropic axis remain unknown. We report here th...

Objective: Modifications in lifestyle and diet are major contributors for the high prevalence of obesity. Very few longitudinal studies have evaluated the changes in body weight over time. Dynamic changes in body weight are also an important indicator of risk for type 2 diabetes. The aim of this study is to assess factors associated with weight gain in a population of Spanish adults.Methods: The study was undertaken in two population-based cohorts of Spa...

Introduction: Kisspeptins, the products of the Kiss1 gene that act via the receptor, GPR54 (or Kiss1R), are pivotal elements in the neuroendocrine control of GnRH neurons and, thereby, gonadotropin secretion. Extensive efforts have been devoted recently to elucidate the pharmacological effects and major putative regulators of the kisspeptin system. Yet, our knowledge on the potential interactions of kisspeptins with other key neurotransmitters involved in the central re...

Introduction: Telehealth systems have become an alternative method to control chronic illnesses like diabetes. The aim of this study was to evaluate a telehealth system in patients with type 1 diabetes who have an optimized treatment with an insulin pump and real-time continuous glucose monitoring system.Research design and methods: Prospective, 1-year study of 15 patients with a continuous insulin infusion system and a real time glucose sensor. Three me...

Introduction: Several studies have shown that treatment with insulin pump is an effective therapy for selected type 1 diabetes. Nevertheless, most of them analyse results in short period of time. The objective of this study is to evaluate long term effects on quality of life (DQOL) and metabolic control of CSII.Material and methods: We did a longitudinal study of type 1 diabetic patients previously treated with multiple daily insulin (MDI) therapy who in...

Introduction: Simultaneous pancreas kidney transplant (SPK) is a prime line treatment option in patients with type 1 diabetes and chronic kidney failure. The glucose control during perioperatory period can be a prognostic factor for transplant. Actually, the utility of the continuous glucose monitoring is not well defined. Our objective was to study the utility of a continuous glucose monitoring system during the simultaneous pancreas kidney transplant.M...

Various risk factors act synergistically for the development of micro and macrovascular complications in type 2 diabetes mellitus (T2DM) patients. The contributions of risk factors have yet to be clearly identified and quantified, but diabetic dyslipidaemia has specific importance.Objective: To investigate the association of dyslipidaemia with micro and macrovascular complications in a T2DM population.Materials and methods: Cross s...

The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was recently identified as central anorexigenic molecule, acting in a leptin-independent manner. Yet, its potential involvement in the regulation of other biological functions gated by body energy status remains unexplored. We show herein that NUCB2/nesfatin-1 is involved in the control of female puberty. NUCB2/nesfatin mRNA and protein were detected at the hypothalamus of pubertal fem...

Purposes: To report the prevalence of obesity, metabolic syndrome (MS) and its related components among adolescents living in the city of Almería (south of Spain). To examine the distribution of HOMA-IR (homeostasis model assessment of insulin resistance).Methods: A total of 373 subjects attending secundary school (aged 12–17 years) participated in a community-based cross-sectional survey. IOTF (International Obesity Task Force) criteria were u...

Background: Retrospective, transversal and analytical study was designed to determine the relationship between ApoB/ApoA1 ratio, Non-HDL-Cholesterol/HDL-Cholesterol ratio and Metabolic Syndrome (MetS) in type 2 diabetes mellitus (T2DM) patients attending routine follow-up in outpatient clinic from Madrid.Methods: The study was performed at the University Hospital Infanta Leonor, a public health center, and specialized secondary referal, which provides se...